The Night Synthesis
The Night Synthesis
The Night Synthesis
The Night Synthesis
The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background
The Night Synthesis
The Night Synthesis
The Night Synthesis
The Night Synthesis
The Night Synthesis
The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background

The Night Synthesis

$198.00
Shipping calculated at checkout.
Rated 4.8 out of 5
Based on 68 reviews

Our 2025 best-selling formula: this clinically proven age-defying concentrate and skin-renewing night cream harnesses the transformative power of Bio-Theriac® complex in a buttery texture that works with your skin while you sleep to visibly reduce the number and severity of fine lines and wrinkles while helping calm irritation. 

Top 3 Reasons to Choose The Night Synthesis:

  1. Cellular repair occurs at night while we sleep
  2. Locking moisturize onto the skin at night helps to decrease transepidermal water loss and restore the skin barrier 
  3. Active ingredients are allowed to do their job because they are in contact for an extended period of time 

Appropriate for all skin types, including sensitive, dry, combination, and oily.

Post-Treatment & Post-Procedure Protocol:

Enhance overnight recovery and amplify treatment benefits with this advanced night concentrate designed for post-procedure skin repair. The Night Synthesis harnesses TRPV1 modulation to support the skin's natural regeneration process, making it the perfect complement to nearly all aesthetic procedures such as neurotoxins and injectables (like Botox, Dysport, Xeomin, Jeuveau, etc) and fillers to lasers (both ablative and non, like Fraxel, Moxi, Morpheus8, IPL), peels, microneedling and more - even after surgical treatments. Clinical trials demonstrate significant improvements in skin texture and erythema reduction, ensuring your aesthetic investments continue working while you sleep to deliver sustained, visible results. As always consult with your physician or practitioner on post-procedure recovery.

Ingredients

Aqua/Water/Eau, Ethylhexyl Olivate, Cocos Nucifera (Coconut) Oil, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Niacinamide, Glycerin, Cetyl Alcohol, Glyceryl Stearate Citrate, Butylene Glycol, Persea Gratissima (Avocado) Oil, Maltodextrin, Polyglyceryl-3 Stearate, Hydrogenated Lecithin, Caprylyl Glycol, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Squalane, Hydroxyacetophenone, Sodium Hyaluronate, Sodium Hydroxide, Sodium Phytate, Nasturtium Officinale Flower/Leaf/Stem Extract, Phenethyl Alcohol, Equisetum Arvense Extract, Urtica Dioica (Nettle) Extract, Pentapeptide-59, Tocopherol, Ethylhexylglycerin, Sodium Chloride
How to Use

Gently massage the skin renewing night cream and concentrate on the face and neck before bed. Use nightly.
Size 50 mL
ALWAYS TESTED ON SENSITIVE SKIN ALWAYS TESTED ON SENSITIVE SKIN
PARABEN, FRAGRANCE, AND DYE-FREE PARABEN, FRAGRANCE, AND DYE-FREE
DERMATOLOGIST APPROVED DERMATOLOGIST APPROVED
CERTIFIED CRUELTY FREE CERTIFIED CRUELTY FREE
ALWAYS TESTED ON SENSITIVE SKIN ALWAYS TESTED ON SENSITIVE SKIN
PARABEN, FRAGRANCE, AND DYE-FREE PARABEN, FRAGRANCE, AND DYE-FREE
DERMATOLOGIST APPROVED DERMATOLOGIST APPROVED
CERTIFIED CRUELTY FREE CERTIFIED CRUELTY FREE

ACTIVE INGREDIENTS

BIO-THERATIC® COMPLEX

Dr. Rossi’s proprietary ingredient composite harnesses the power of biomimetic sea anemone peptide, niacinamide, and hyaluronic acid in a unique, optimized ratio to help fight the visible signs of premature aging caused by sensitization in skin.
NASTURTIUM OFFICINALE AND URTICA DIOICA EXTRACTS

Studies show that these watercress and nettle leaf extracts have high antioxidant activity, helping shield skin against environmental stressors which can lead to premature aging.  
SQUALANE

One of nature’s greatest emollients, this plant-based, lab-fermented squalane helps prevent moisture loss while helping smooth skin and restore elasticity.

Before And After

After Four Weeks

  • 87% Agree Skin Feels More Supple and Elastic*
  • 87% Agree Skin Feels Healthier and Energized*
  • Up to 100% Smoother Skin*
  • Up to 100% Reduction in Redness*

*In a clinical study on 31 men and women 

HOW IT WORKS
Image after
Image before

Best Luxury Skincare Brand

AskMen.com

BEST NIGHTIME CREAM

Martha Stewart Living

 American Contact Dermatitis Society Approved

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Write a Review
average rating 4.8 out of 5
Based on 68 reviews
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68 Reviews
Reviewed by Gerardo C., from United States
Verified Buyer
I recommend this product
Skin Type
Combination
Age Range
55 - 64
Rated 5 out of 5
Review posted

delicious face cream

i have tried many creams, but this one stands out among the rest. its texture is especially firm in a velvety and luxurious way. its applies smoothly and cleanly and brings a firmness and a glow to the skin. overnight, some repair must happen because in the morning, the skin maintains its beautiful glow. fine lines seems less noticeable. i just love this night synthesis.

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Reviewed by Gilberto A., from United States
Verified Buyer
I recommend this product
Skin Type
Combination
Age Range
45 - 54
Rated 5 out of 5
Review posted

Love it

Great feeling! Makes me younger

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Reviewed by Anne B., from United States
Verified Buyer
I recommend this product
Skin Type
Sensitive
Age Range
45 - 54
Rated 5 out of 5
Review posted

Seems to actually treat my rosacea

I will have a few rosacea pustules in the evening, I apply this, and they are often gone in the morning. I am also using prescription rosacea meds under the lotion, but my meds have never worked this well before

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Reviewed by Benjamin
I recommend this product
Rated 5 out of 5
Review posted

5 Stars

Lovely sent and great texture

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Reviewed by Nora D., from United States
Verified Buyer
I recommend this product
Skin Type
Dry
Age Range
45 - 54
Rated 5 out of 5
Review posted

The BEST!!

I have very dry skin that always breaks out.

Such a hard combination!

It’ve tried EVERY skincare line from “science backed” to “dermatologist recommended” to “all natural”. Dr Rossi’s line is the ONLY skincare line that doesn’t break me out! I keep waiting for the other shoe to drop! lol! It’s been 3 weeks and so far so good! 5 stars!!

😊

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