How to Use · The Complete Routine

Complete 6-step skincare routine

A clinical, barrier-supportive regimen designed to calm sensitivity, support healthy aging, and improve the appearance of texture, redness, pores, and skin resilience.

Morning routine

5 steps · AM
The Purifier01

Cleanse

The Purifier Cleanser

Apply to dry or damp skin and massage gently over the face for 30–60 seconds. Add water to emulsify into a soft foam, then rinse thoroughly.

Use on
Face, neck, and chest
Purpose
Removes overnight oil, impurities, and buildup without stripping the skin barrier.
The Solution02

Refine + Resurface

The Solution Exfoliating Essence

After cleansing, apply a small amount to clean, dry skin using fingertips or a cotton round.

Use on
Face, neck, and chest as tolerated
Purpose
Helps smooth texture, improve radiance, reduce the appearance of pores, and calm visible redness.

Sensitive skin Start 2–3 mornings per week, then increase as tolerated.

The Catalyst03

Treat

The Catalyst Serum

Apply 1–2 pumps to the face and gently press into the skin.

Use on
Face, neck, chest, and backs of hands
Purpose
Supports skin renewal, hydration, elasticity, visible redness reduction, and healthy-aging benefits.
The Eye Cure04

Target the Eye Area

The Eye Cure Eye Cream

Apply a rice-grain amount around each eye using the ring finger.

Use on
Under-eye area and orbital bone
Purpose
Hydrates and supports the delicate eye area while improving the look of fatigue, fine lines, and dryness.
The Day Formula05

Protect

The Day Formula Broad Spectrum SPF 30 Mineral Facial Lotion

Apply generously as the final step in the morning.

Use on
Face, neck, chest, ears, and backs of hands
Purpose
Provides daily mineral UV protection while supporting the skin barrier.

Important Reapply every 2 hours when outdoors, sweating, or after swimming.

Evening routine

5 steps · PM
The Purifier01

Cleanse

The Purifier Cleanser

Use as the first step at night to remove sunscreen, makeup, pollutants, oil, and debris from the day. Massage gently and rinse thoroughly.

Use on
Face, neck, and chest
Purpose
Resets the skin after a full day of exposure, prepping the barrier for overnight recovery.
The Solution02

Refine

The Solution Exfoliating Essence

Apply after cleansing if your skin is tolerating it well.

Use on
Face, neck, and chest as tolerated
Purpose
Continues to refine texture and clarity overnight when skin is most receptive.

Nighttime tip If using prescription retinoids, strong acids, or other active treatments, alternate nights to avoid irritation.

The Catalyst03

Repair + Restore

The Catalyst Serum

Apply 1–2 pumps after The Solution, or directly after cleansing on more sensitive nights.

Use on
Face, neck, chest, and backs of hands
Purpose
Drives overnight renewal and barrier repair while skin regenerates.
The Eye Cure04

Hydrate Eye Area

The Eye Cure Eye Cream

Apply gently around the eyes. Avoid placing product too close to the lash line.

Use on
Under-eye area and orbital bone
Purpose
Supports the delicate eye area overnight, easing the look of dryness and fatigue.
The Night Synthesis05

Seal + Recover

The Night Synthesis Night Cream

Apply as the final step before bed.

Use on
Face, neck, and chest
Purpose
Locks in hydration, supports overnight barrier repair, and helps skin recover while you sleep.

Simple routine for sensitive or irritated skin

If skin feels dry, irritated, red, or reactive, simplify down to the essentials.

Morning

The Purifier→ The Catalyst→ The Day Formula

Evening

The Purifier→ The Catalyst→ The Night Synthesis

Hold The Solution until skin feels calm again.

Post-procedure routine

After lasers, microneedling, peels, or energy-based treatments, follow your provider’s instructions first.

Morning

The Purifier→ The Catalyst→ The Day Formula

Evening

The Purifier→ The Catalyst→ The Night Synthesis

Avoid The Solution until the skin barrier has fully recovered or your provider clears you to restart exfoliating products.

Quick reference

Order of application

1

Cleanse

The Purifier

2

Exfoliate

The Solution

3

Treat

The Catalyst

4

Eyes

The Eye Cure

5

Moisturize

The Night Synthesis

PM
6

Protect

The Day Formula

AM only

Apply in this order, top to bottom. SPF is the final step in the morning only — swap in The Night Synthesis at night.

Watch

See the routine in action

Step-by-step application guides for every product in the lineup.

View the full playlist on YouTube →

The Science

How Biotheriac protects collagen

Figure 1

Biotheriac TRPV1 Antagonism

Without treatment

Environmental Stressors
UV · Heat · ROS · Irritants
TRPV1 — Open
Ca²⁺ influx triggered
NF-κB · MAPK · PKC
Kinase cascade activated
MMPs Upregulated
MMP-1 · MMP-2 · MMP-9

Collagen degraded

Photoaging
Wrinkles · Elasticity loss · Redness
VS

With Biotheriac

Environmental Stressors
UV · Heat · ROS · Irritants
TRPV1 — Blocked
Calcium entry prevented
Biotheriac Peptide
Cascade Halted
NF-κB · MAPK · MMP suppressed
Niacinamide
Suppresses NF-κB · rebuilds barrier
Hyaluronic Acid
Restores matrix · reduces redness

Collagen preserved

Healthy, Resilient Skin
Calm · Firm · Even · Hydrated
Stressor / activation pathway
Biotheriac TRPV1 block
Ca²⁺ ion flux (active)
Ca²⁺ flux suppressed
Intact collagen preserved
Degraded collagen

Figure 1. Biotheriac Complex — mechanism of TRPV1 antagonism. Without intervention, environmental stressors activate TRPV1, causing Ca²⁺ influx, kinase cascade amplification, MMP upregulation, collagen degradation, and ultimately photoaging. The Biotheriac biomimetic peptide binds and blocks TRPV1 before calcium can enter, halting the cascade — resulting in calm, firm, hydrated skin.

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