Product image of skin renewing night cream The Night Synthesis by Dr. Rossi DERM MD
closeup of smear of cream-colored skincare night cream, on white background
The Night Synthesis
Two images of a man's brow from The Night Synthesis clinical trials. Image on the top displays man's brow before using The Night Synthesis, and the image on the bottom shows his brow after using The Night Synthesis for four weeks.
Two side-by-side images of a woman's cheek from The Night Synthesis clinical trials. Image on the left displays woman's cheek before using The Night Synthesis, and the image on the right shows her cheek after using The Night Synthesis for four weeks.
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
Product image of skin renewing night cream The Night Synthesis by Dr. Rossi DERM MD
closeup of smear of cream-colored skincare night cream, on white background
The Night Synthesis
Two images of a man's brow from The Night Synthesis clinical trials. Image on the top displays man's brow before using The Night Synthesis, and the image on the bottom shows his brow after using The Night Synthesis for four weeks.
Two side-by-side images of a woman's cheek from The Night Synthesis clinical trials. Image on the left displays woman's cheek before using The Night Synthesis, and the image on the right shows her cheek after using The Night Synthesis for four weeks.
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
Rated 4.8 out of 5
Based on 57 reviews

The Night Synthesis

Sale Save

Restructuring concentrate

Martha Stewart's Beauty recommends Dr. Rossi's The Night Synthesis.

Size 50 mL
+
It’s Holiday time! 30% OFF on all items with offer code: HOLIDAY30
FREE SHIPPING ON ALL ORDERS!

SUSTAINABLE BEAUTY

ALWAYS TESTED ON SENSITIVE SKIN

PARABEN, FRAGRANCE, AND DYE-FREE

DERMATOLOGIST APPROVED

CERTIFIED CRUELTY FREE

Approved and recognized by The North American Contact Dermatitis Society

This clinically proven age-defying concentrate and skin-renewing night cream harnesses the transformative power of Bio-Theriac® complex in a buttery texture that works with your skin while you sleep to visibly reduce the number and severity of fine lines and wrinkles while helping calm irritation. It is our 2024 Best Seller.

Top 3 Reasons to Choose The Night Synthesis:

  1. Cellular repair occurs at night while we sleep
  2. Locking moisturize onto the skin at night helps to decrease transepidermal water loss and restore the skin barrier 
  3. Active ingredients are allowed to do their job because they are in contact for an extended period of time 

Appropriate for all skin types, including sensitive, dry, combination, and oily.

Key Ingredients

Bio-Theriac® complex

Dr. Rossi’s proprietary ingredient composite harnesses the power of biomimetic sea anemone peptide, niacinamide, and hyaluronic acid in a unique, optimized ratio to help fight the visible signs of premature aging caused by sensitization in skin.

Nasturtium Officinale and Urtica Dioica Extracts

Studies show that these watercress and nettle leaf extracts have high antioxidant activity, helping shield skin against environmental stressors which can lead to premature aging.  

Squalane 

One of nature’s greatest emollients, this plant-based, lab-fermented squalane helps prevent moisture loss while helping smooth skin and restore elasticity.

Aqua/Water/Eau, Ethylhexyl Olivate, Cocos Nucifera (Coconut) Oil, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Niacinamide, Glycerin, Cetyl Alcohol, Glyceryl Stearate Citrate, Butylene Glycol, Persea Gratissima (Avocado) Oil, Maltodextrin, Polyglyceryl-3 Stearate, Hydrogenated Lecithin, Caprylyl Glycol, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Squalane, Hydroxyacetophenone, Sodium Hyaluronate, Sodium Hydroxide, Sodium Phytate, Nasturtium Officinale Flower/Leaf/Stem Extract, Phenethyl Alcohol, Equisetum Arvense Extract, Urtica Dioica (Nettle) Extract, Pentapeptide-59, Tocopherol, Ethylhexylglycerin, Sodium Chloride

Gently massage the skin renewing night cream and concentrate on the face and neck before bed. Use nightly.

Goes well with

 

As seen in

CLINICAL TRIAL RESULTS

Before and after results of person’s face before and after using the skin renewing night cream, The Night Synthesis
AFTER 4 WEEKS
Before and after results of person’s face before and after using the skin renewing night cream, The Night Synthesis
BEFORE
AFTER 4 WEEKS
  • 87% Agree Skin Feels More Supple and Elastic*
  • 87% Agree Skin Feels Healthier and Energized*
  • Up to 100% Smoother Skin*
  • Up to 100% Reduction in Redness*

*In a clinical study on 31 men and women 

WHY DR. ROSSI?

SENSITIVE SKIN, SPECIAL CARE

Dr. Rossi embarked on a mission to rethink skin care and create de-aging solutions appropriate for all, regardless of age, gender, or level of skin sensitivity. His goal: To combat the signs of skin aging while suppressing sensitization.

After treating both those patients battling cancer and those seeking cosmetic treatments, Dr. Rossi noticed that when his patients looked better, they felt better and healed more quickly. But his patients with sensitive skin couldn’t get the results they wanted because products in the market aggravated their sensitivity.

THE BREAKTHROUGH

Dr. Rossi developed his landmark formulas with his proprietary Bio-Theriac® complex, which helps correct the visible effects of aging and environmental aggressors while reducing sensitization. Dr. Rossi’s formulas exclude the use of ingredients that neither support skin health nor aid in its appearance, such as irritants, fillers, and fragrance.

The result is a relentlessly perfected and tested, revolutionary line of luxury treatments that will reveal your healthiest looking, most vibrant skin regardless of your gender identity, complexion, or skin condition. 

NEXT-GENERATION MEDICAL-GRADE SKIN CARE

"Skin sensitivity is not just discomfort—it can be tied to one of the root causes of premature skin aging. What we put on our skin matters, so if a product causes irritation it’s a big red flag and you’re probably doing more harm than good to your skin. I created this line of clean, high-performing products to restore skin to its youthful, healthy look while remaining non-irritating and safe to use on all skin types, including on the skin conditions of my cancer patients. This type of medical-grade skin care has never been done before."

Banner Image

FAQ – The Night Synthesis Concentrate and Skin Renewing Night Cream

Yes, incorporating a night cream into your routine offers numerous benefits for your skin. Night creams can replenish the moisture that’s lost during the day and also repair damage from environmental stressors like pollution and UV rays. Some night creams contain anti-aging ingredients like retinol or peptides that can help stimulate collagen production and improve skin elasticity over time. Using this type of product can help you wake up with a more radiant, youthful, and hydrated complexion.

Night creams serve a different purpose from moisturizers. They are specially formulated for deep hydration and nourishment while you sleep, containing peptides, ceramides, enzymes, and antioxidants. The ingredients work to help repair and regenerate skin cells overnight, and the lotion formula is often more emollient and rich to target skin concerns, such as fine lines, wrinkles, and dullness. 

Daytime moisturizers, on the other hand, are designed to provide lightweight hydration and also function as sunscreen. Most often, they contain SPF to shield the skin from UV rays and maintain skin health throughout the day. Typically, it’s best to use a moisturizer during the day and a nourishing night cream in the evening for a well-rounded skincare regimen.

To use a night cream effectively, start by washing your face with a cleanser to remove any impurities and makeup residue. Gentle exfoliation can also help prep the skin for a heavier cream. Then, use a toner and apply your desired serum, if any. 

After the skin is clean and prepped, apply a generous amount of the best night time cream onto your fingertips and gently massage it onto your face and neck using upward and outward motions. This allows the cream to be absorbed effectively into the skin, ensuring maximum benefits overnight.

Unlike traditional night creams, The Restructuring Concentrate Night Synthesis harnesses the power of innovative technology and cutting-edge research to transform your skin while you sleep. The science-backed formula contains a high concentration of peptides, antioxidants, hyaluronic acid, and niacinamide to prevent moisture loss and restore elasticity. It’s an innovation using plant-based lab-fermented squalane, perfected and tested to reveal vibrant, healthy-looking skin. The clinical trial results also prove the product's efficacy.

average rating 4.8 out of 5
Based on 57 reviews
  • 5 Stars
    45 Reviews
  • 4 Stars
    12 Reviews
  • 3 Stars
    0 Reviews
  • 2 Stars
    0 Reviews
  • 1 Star
    0 Reviews
100% of reviewers would recommend this product to a friend
Customer photos and videos
57 Reviews
Reviewed by TRACY G., from United States
Verified Buyer
I recommend this product
Skin Type
Sensitive
Age Range
55 - 64
Rated 5 out of 5
Review posted

Great night cream

I have very sensitive skin and can become irritated when using retinols. I use this and it’s so soothing and moisturizing for my skin. I love it! Thank you Dr. Rossi!

Loading...
Was this helpful?
Reviewed by G M., from United States
Verified Buyer
I recommend this product
Skin Type
Dry
Age Range
65+
Rated 5 out of 5
Review posted

The Night Synthesis

Use daily. Love the product!

Loading...
Was this helpful?
Reviewed by Maryann T., from United States
Verified Buyer
I recommend this product
Skin Type
Sensitive
Age Range
65+
Rated 5 out of 5
Review posted

A product that delivers

Love it! After a few nights, I noticed amazing hydration, diminished wrinkles, and overall more consistent skin tone. I have very sensitive skin and am prone to rosacea. There were no issues using this night cream. Looking forward to ordering and using more DrRossiDERM.

Loading...
Was this helpful?
Reviewed by Margarita O., from United States
Verified Buyer
I recommend this product
Skin Type
Dry
Age Range
65+
Rated 5 out of 5
Review posted

Night synthesis

I like the night synthesis. Very much the only thing I found is a bit dry. Other wise is great

Loading...
Was this helpful?
Reviewed by Briana I., from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

Glowy

One of my favorite moisturizers to date! I struggle with red acne scars and texturized skin, but this moisturizer has helped me regain my confidence and treat my complicated skin. I have also noticed a difference in the strength of my skin which feels more tight and glowy. I can now achieve the natural makeup look I've wanted my whole life because of how amazing this moisturizer is.

Loading...
Was this helpful?